Large inventory of drugs to deal with premature ejaculation!
Recent ejaculation effects of drugs on a number of findings have been so that we may begin to understand the neurological mechanism of premature ejaculation. For example, the pseudo-ephedrine, ephedrine, phenylpropanolamine hydrochloride and other drugs can increase sympathetic nerve activity and thus promote male ejaculation ejaculation disorders. Interestingly, there are reports that they are now taking clomipramine may suffer and yawning related to orgasm, while the patients taking Fluoxetine increases with the dose will appear spontaneous orgasm. These findings led to a large number of studies of drugs to delay ejaculation, in which the main three kinds of drugs dopamine antagonists, antidepressants, and antianxiety drugs.
◆ ◆ dopamine antagonist
Such drugs, including antipsychotics (also known as antipsychotics) can block central dopamine receptors. By observing the apomorphine (dopamine agonist) in the role of sexual arousal can be haloperidol (central dopamine receptor blocker) the antagonist, can also be atypical dopamine receptor antagonist by sulfur Benzamides antagonistic, but it was not not pass the blood brain barrier dopamine receptor antagonist domperidone antagonized by the facts of the drugs on delayed ejaculation is influential. Dopamine antagonist on humans or animals show a clear role in suppression of ejaculation, including pimozide (antipsychotic), metoclopramide (antiemetic drugs), sulfur benzene amide, haloperidol, and oxytocin antagonist, possession of oxytocin. Others can delay ejaculation antipsychotics, including chlorpromazine and thioridazine, both drugs can also block adrenergic receptors.
◆ ◆ antidepressants
Delayed ejaculation is a new generation antidepressant drugs, it can enhance the human body, 5 – hydroxytryptamine (5-HT) levels. These drugs include the 5-HT selective reuptake inhibitors (SSRIs) Fluoxetine, Sertraline, and Paroxetine. These drugs block 5-HT reuptake at the same time, there are anti-cholinergic effect. Elevated levels of 5-HT is considered one of the mechanisms inhibiting ejaculation. The older tricyclic antidepressants also affect ejaculation. These drugs have a calming, anti-cholinergic and anti-histamine properties, in addition to prevent the re-uptake of 5-HT. However, these drugs hinder the role of 5-HT reuptake selective small, and their other characteristics of the patient’s compliance may have a negative impact. Among these drugs clomipramine on 5-HT and norepinephrine reuptake have them back. Clomipramine can enhance genital receptor stimulation thresholds, but the right sacral nerve to stimulate the dorsal body reactions or feelings aroused potential of no effect. Another inhibitory effect of ejaculation is a tricyclic antidepressant amitriptyline, which has significant anti-cholinergic effect.
A recent study of Fluoxetine, sertraline, clomipramine in the treatment of premature ejaculation on the effectiveness and safety compared the results with Fluoxetine or placebo taking clomipramine and dwelling Qu Lin can significantly improve vaginal ejaculation latency. Although there is no statistical support, but the patients taking clomipramine their sexual partner’s sexual satisfaction rate than taking the other two drugs is higher. Therefore, effective speaking, clomipramine is the most effective, followed by sertraline but its relatively low incidence of side effects.
◆ ◆ anti-anxiety drugs
Known to many for the treatment of generalized anxiety and anxiety attacks Benzodiazepine anti-anxiety drugs on the part of the class of men the role of inhibited ejaculation and its mechanism may be enhanced GABA (g-amino butyric acid). These drugs include chlordiazepoxide, lorazepam, alprazolam. But their impact on ejaculation than other drugs (such as SSRIs) as the universal and obvious, placebo-controlled studies have shown that men taking these drugs less than 10% of the people than before ejaculation delayed.
Ding spiral one, is not a complete 5-HT agonist, can improve sexual function of patients with generalized anxiety.